Kimiyuki Shibuya: search on Z-Library

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1

A Novel Allylic Oxidation Using a Combination of Formic Acid and Selenium Dioxide

Shibuya, Kimiyuki

Journal:

Synthetic Communications

Year:

1994

Language:

english

File:

PDF, 629 KB

english, 1994

2

Total synthesis of upial

Hiroto Nagaoka, Kimiyuki Shibuya, Yasuji Yamada

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 301 KB

english, 1993

3

A New Synthetic Route to the Corynanthe Type Indole Alkaloids Using (±)-Norcamphor

Takano, Seiichi, Takahashi, Mikito, Hatakeyama, Susumu, Ogasawara, Kunio, Shibuya, Kimiyuki

Journal:

Year:

1981

Language:

english

File:

PDF, 157 KB

english, 1981

4

Discovery of novel spiro[chromane-2,4′-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists

Koshizawa, Tomoaki, Morimoto, Toshiharu, Watanabe, Gen, Fukuda, Tomoaki, Yamasaki, Nao, Hagita, Sumihiko, Sawada, Yoshikazu, Okuda, Ayumu, Shibuya, Kimiyuki, Ohgiya, Tadaaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2018

Language:

english

File:

PDF, 711 KB

english, 2018

5

ChemInform Abstract: A Practical Synthesis of Novel Rho-Kinase Inhibitor, (S)-4-Fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline.

Noriaki Gomi, Tadaaki Ohgiya, Kimiyuki Shibuya, Jyunji Katsuyama, Masayuki Masumoto, Hitoshi Sakai

Journal:

Year:

2011

File:

PDF, 42 KB

2011

6

Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist

Koura, Minoru, Yamaguchi, Yuki, Kurobuchi, Sayaka, Sumida, Hisashi, Watanabe, Yuichiro, Enomoto, Takashi, Matsuda, Takayuki, Okuda, Ayumu, Koshizawa, Tomoaki, Matsumoto, Yuki, Shibuya, Kimiyuki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 749 KB

english, 2016

7

Total synthesis of upial, a marine sesquiterpene possessing bicyclo[3.3.1]nonane ring system

Hiroto Nagaoka, Kimiyuki Shibuya, Yasuji Yamada

Journal:

Year:

1994

Language:

english

File:

PDF, 2.13 MB

english, 1994

8

A Facile Synthesis of 3-(2-Amino-4-ethoxyphenyl)pyridine

Ohta, Tomio, Shibuya, Kimiyuki, Shigyo, Hiromichi

Journal:

Year:

1990

Language:

english

File:

PDF, 152 KB

english, 1990

9

Synthesis of optically active bicyclo[2.2.2]octanes. Substitution effect of the cyclohexenone ring on the sequential Michael reaction

Hiroto Nagaoka, Kimiyuki Shibuya, Kaoru Kobayashi, Isao Miura, Michitaka Muramatsu, Yasuji Yamada

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 309 KB

english, 1993

10

Body Length Composition and Recruitment Time of Hime Salmon Oncorhynchus nerka in Lake Chuzenji Judged by Experimental Fishing.

Yoshihara, Kiyoshi, Okumoto, Naoto, Shikama, Toshio, Oda, Saburo, Ishijima, Hisao, Shibuya, Takayuki, Kamiyama, Kimiyuki, Soeda, Hideo

Journal:

NIPPON SUISAN GAKKAISHI

Year:

1991

Language:

english

File:

PDF, 579 KB

english, 1991

11

Novel Synthesis of Butyl (S)-2-Hydroxybutanoate, the Key Intermediate of PPARα Agonist (R)-K-13675 from Butyl (2S,3R)-Epoxybutanoate and Butyl (S)-2,3-Epoxypropanoate

Araki, Takaaki, Koura, Minoru, Yamazaki, Yukiyoshi, Shibuya, Kimiyuki

Journal:

Year:

2013

Language:

english

File:

PDF, 204 KB

english, 2013

12

Synthesis of highly deuterium-labeled (R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Yukiyoshi Yamazaki, Shin-ichiro Ogawa, Kimiyuki Shibuya

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 593 KB

english, 2009

13

A practical synthesis for (S)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione and its application in the synthesis of a novel liver X receptor β-selective agonist

Koura, Minoru, Sumida, Hisashi, Yamazaki, Yukiyoshi, Shibuya, Kimiyuki

Journal:

Tetrahedron: Asymmetry

Year:

2016

Language:

english

File:

PDF, 944 KB

english, 2016

14

A new method for the synthesis of spiro ?-butyrolactone via samarium(II) iodide-induced cyclization

Shibuya, Kimiyuki, Nagaoka, Hiroto, Yamada, Yasuji

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 182 KB

english, 1991

15

A practical synthesis of the PPARα agonist, (R)-K-13675, starting from (S)-2-hydroxybutyrolactone

Yukiyoshi Yamazaki, Takaaki Araki, Minoru Koura, Kimiyuki Shibuya

Journal:

Year:

2008

Language:

english

File:

PDF, 284 KB

english, 2008

16

Synthesis and Antiarrhythmic Activity of Disubstituted Phenylpyridine Derivative.

SHIGYO, Hiromichi, SATO, Seiichi, SHIBUYA, Kimiyuki, TAKAHASHI, Yoshio, YAMAGUCHI, Takashi, SONOKI, Hiroyuki, OHTA, Tomio

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

1993

File:

PDF, 1.28 MB

1993

17

Optimization of a novel series of potent and orally bioavailable GPR119 agonists

Koshizawa, Tomoaki, Morimoto, Toshiharu, Watanabe, Gen, Watanabe, Toshiaki, Yamasaki, Nao, Sawada, Yoshikazu, Fukuda, Tomoaki, Okuda, Ayumu, Shibuya, Kimiyuki, Ohgiya, Tadaaki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 735 KB

english, 2017

18

Discovery of the Clinical Candidate 2-(4-(2-((1 H -benzo[ d ]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N -(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide hydrocholoride [K-604], an Aqueous Soluble Acyl-CoA: Cholesterol O -Acyltransferase (ACAT/SOAT)-1 Inhibitor

Shibuya, Kimiyuki, Kawamine, Katsumi, Ozaki, Chiyoka, Ohgiya, Tadaaki, Edano, Toshiyuki, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 842 KB

english, 2018

19

Crystal structures of ( S )-(+)-5-(3-bromo/chloro-4-isopropoxyphenyl)-5-methylimidazolidine-2,4-dione

Ohba, Shigeru, Koura, Minoru, Sumida, Hisashi, Shibuya, Kimiyuki

Journal:

Acta Crystallographica Section E Crystallographic Communications

Year:

2016

Language:

english

File:

PDF, 654 KB

english, 2016

20

A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels

Mami Ikenoya, Yasunobu Yoshinaka, Hideyuki Kobayashi, Katsumi Kawamine, Kimiyuki Shibuya, Fumiyasu Sato, Kimio Sawanobori, Takuya Watanabe, Akira Miyazaki

Journal:

Atherosclerosis

Year:

2007

Language:

english

File:

PDF, 528 KB

english, 2007

21

New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism

Miyosawa, Katsutoshi, Watanabe, Yuichiro, Murakami, Kentaro, Murakami, Takeshi, Shibata, Haruki, Iwashita, Masaya, Yamazaki, Hiroyuki, Yamazaki, Koichi, Ohgiya, Tadaaki, Shibuya, Kimiyuki, Mizuno, Ken

Journal:

AJP Endocrinology and Metabolism

Year:

2015

Language:

english

File:

PDF, 4.11 MB

english, 2015

22

A Practical Synthesis of (4-(Spiro[chromane-2,4'-piperidin]-6-yl)phenyl)methanol as a Key Intermediate of Novel GPR119 Agonist

Shibuya, Kimiyuki, Koshizawa, Tomoaki, Hosoi, Hayato, Watanabe, Gen, Morimoto, Toshiharu, Ohgiya, Tadaaki

Journal:

Year:

2014

Language:

english

File:

PDF, 746 KB

english, 2014

23

Design, synthesis and pharmacology of aortic-selective acyl-CoA: Cholesterol O -acyltransferase (ACAT/SOAT) inhibitors

Shibuya, Kimiyuki, Kawamine, Katsumi, Miura, Toru, Ozaki, Chiyoka, Edano, Toshiyuki, Mizuno, Ken, Yoshinaka, Yasunobu, Tsunenari, Yoshihiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.16 MB

english, 2018

24

Design and discovery of 2-oxochromene derivatives as liver X receptor β-selective agonists

Matsuda, Takayuki, Okuda, Ayumu, Watanabe, Yuichiro, Miura, Tohru, Ozawa, Hidefumi, Tosaka, Ayako, Yamazaki, Koichi, Yamaguchi, Yuki, Kurobuchi, Sayaka, Koura, Minoru, Shibuya, Kimiyuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1022 KB

english, 2015

25

Determination of the Absolute Configuration and a Practical Chiral Synthesis of 5-[5-(1-Methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione as a Novel Liver X Receptor β-Selective Agonist

Koura, Minoru, Sumida, Hisashi, Shibuya, Kimiyuki, Ohba, Shigeru

Journal:

Year:

2017

Language:

english

File:

PDF, 329 KB

english, 2017

26

A Practical Synthesis of Novel Rho-Kinase Inhibitor, (S)-4-Fluoro-5-(2-methyl-1,4-diazepan-1-ylsulfonyl)isoquinoline

Shibuya, Kimiyuki, Gomi, Noriaki, Ohgiya, Tadaaki, Katsuyama, Jyunji, Masumoto, Masayuki, Sakai, Hitoshi

Journal:

Year:

2011

Language:

english

File:

PDF, 793 KB

english, 2011

27

A selective ACAT-1 inhibitor, K-604, stimulates collagen production in cultured smooth muscle cells and alters plaque phenotype in apolipoprotein E-knockout mice

Yasunobu Yoshinaka, Haruki Shibata, Hideyuki Kobayashi, Hiroki Kuriyama, Kimiyuki Shibuya, Sohei Tanabe, Takuya Watanabe, Akira Miyazaki

Journal:

Atherosclerosis

Year:

2010

Language:

english

File:

PDF, 1.38 MB

english, 2010

28

A facile method for converting alcohol to thioether and its application in the synthesis of a novel GPR119 agonist

Koshizawa, Tomoaki, Yamazaki, Yukiyoshi, Ohgiya, Tadaaki, Shibuya, Kimiyuki

Journal:

Year:

2015

Language:

english

File:

PDF, 541 KB

english, 2015

29

A Practical Synthesis of (S)-tert-Butyl 3-Methyl-1,4-diazepane-1-carboxylate, the Key Intermediate of Rho–Kinase Inhibitor K-115

Gomi, Noriaki, Kouketsu, Akiyasu, Ohgiya, Tadaaki, Shibuya, Kimiyuki

Journal:

Year:

2012

Language:

english

File:

PDF, 227 KB

english, 2012

30

Syntheses and pharmacokinetic evaluations of four metabolites of 2-(4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis-(methylthio)pyridin-3-yl)acetamide hydrochloride [K-604], an acyl-CoA:cholesterol O-acyltransferase-1 inhibitor

Shibuya, Kimiyuki, Miura, Toru, Ohgiya, Tadaaki, Omichi, Kozo, Tsunenari, Yoshihiko

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 940 KB

2020

31

Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death

Shibuya, Kimiyuki, Watanabe, Toshiaki, Urano, Yasuomi, Takabe, Wakako, Noguchi, Noriko, Kitagishi, Hiroaki

Journal:

Bioorganic & Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 748 KB

english, 2016

32

Enantioselective Synthesis of the PPARα Agonist ( R )-K-13675 via ( S )-2-Hydroxybutyrolactone

Yamazaki, Yukiyoshi, Araki, Takaaki, Koura, Minoru, Shibuya, Kimiyuki

Journal:

Year:

2008

Language:

english

File:

PDF, 133 KB

english, 2008

33

Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists

Yukiyoshi Yamazaki, Kazutoyo Abe, Tsutomu Toma, Masahiro Nishikawa, Hidefumi Ozawa, Ayumu Okuda, Takaaki Araki, Soichi Oda, Keisuke Inoue, Kimiyuki Shibuya, Bart Staels, Jean-Charles Fruchart

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

34

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists

Koura, Minoru, Matsuda, Takayuki, Okuda, Ayumu, Watanabe, Yuichiro, Yamaguchi, Yuki, Kurobuchi, Sayaka, Matsumoto, Yuuki, Shibuya, Kimiyuki

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 1.46 MB

english, 2015

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